The Admiral of the Portuguese Navy, Henrique Gouveia e Melo, candidate for the Presidency of the Republic, recently stated that after ten years an immigrant becomes as Portuguese as we are, or else we possess a special gene. Such a statement, clothed in apparent simplicity, betrays a troubling ignorance of the moral, historical, and spiritual essence that defines Portuguese identity.
PEAPACK & GLADSTONE, NJ — The Peapack & Gladstone Police Department is the recipient of a generous donation from the DePaço Foundation of Lebanon (depacofoundation.org) to be used towards the purchase of a new police vehicle.
Great to be in Bernardsville tonight with supporters who are ready for change.
People are tired of the status quo — tired of the same failed policies that gave us the highest taxes in the nation, made New Jersey the worst state to retire in and the worst state to do business in, and left us with schools that are failing our kids and producing students who can’t read at grade level.
Chondroitin sulfate (CS) plays important roles in the complement system. However, the CS structure is complicated due to different sources and the number and positions of sulfate groups.
Many studies have shown that microgravity experienced by astronauts or long-term bedridden patients results in increased oxidative stress and bone loss. Low-molecular-weight chondroitin sulfates (LMWCSs) prepared from intact chondroitin sulfate (CS) have been demonstrated to possess good antioxidant and osteogenic activities in vitro.
Chondroitin sulfate has been widely administered orally to improve knee osteoarthritis. Chondroitin sulfate also has various biological properties, such as anti-inflammatory, immunomodulatory, anti-oxidative, and antitumor activity. However, chondroitin sulfate absorption in the digestive system and bioavailability remains controversial owing to its large molecular weight.
Osteoarthritis is primarily characterized by areas of destruction of articular cartilage and by synovitis. Articular damage and synovitis are secondary to local increase of pro-inflammatory cytokines (interleukin-1β and tumor necrosis factor-α), enzymes with proteolytic activity (matrix metalloproteinases), and enzymes with pro-inflammatory activity (cyclooxygenase-2 and nitric oxide synthase-2).
Chondroitin sulfate (CS) is a sulfated linear polysaccharide with different functional activities, including antioxidant, anti-inflammatory, lipid-lowering, and immune regulation.
Currently, colorectal cancer is the third most common cancer in the world. Recently, glucosamine and chondroitin have gained popularity for their beneficial effects on cancer. They have already been recognized for their therapeutic role in osteoarthritis.
Studies have shown an inverse association between use of glucosamine and chondroitin supplements and colorectal cancer risk. However, the association with the precursor lesion, colorectal adenoma and serrated polyp, has not been examined.
